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Lancet Healthy Longevity 3 , 6777 (2022)

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Review for any drug-drug interactions (especially with valproic acid, phenobarbital, or phenytoin)

Therefore the discovery of Leptin has been received with great expectation as a potential anti-obesity therapy due to its ability to reverse excess adiposity in animal models (rodents) characterized by a deficiency of the hormone, in fact, leptin reduces body weight dramatically, suppresses appetitive behaviors and improves other endocrine-sensitive and metabolic leptin abnormalities in children and adults with congenital hormone deficiency

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