The two rest days are not strictly necessary but are a common precaution to manage cumulative copper exposure over longer cycles
So if you dont replenish your vitamin B12 level within 3 years, your body will use up all the stored B12 and become B12 deficient
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B-100 complex can interfere with other medications including but not limited to levodopa, medicines containing oestrogen, hydrazine, certain anti epileptic drugs, phenobaritone, phenytoin, immunosuppressants and some medicines used to treat infections such as isoniazid, pyrazinamide, cycloserne and penicillamine
However the blood level of serum B12 rises regardless of therapeutic effectiveness
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