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The contradictory response of glutathione gel in the treatment of melasma in different studies may be attributed to the difference in stability, absorption, penetration of glutathione and affected by the different vehicle (soap, cream, gel or lotion) rather than the efficacy of glutathione itself

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Many women describe the following changes within the first few weeks or months: These are usually temporary and non-toxic

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The activation of astrocytes exerts highly context-dependent functions that vary along the temporal course of disease, the nature of the pathological milieu and their heterogeneous transcriptional states

doi: 10.1073/pnas.1109478108 55 RobsonAHarrisLKInnesBALashGEAljunaidyMMAplinJDet al