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The Wegovy SmPC notes that while gastric emptying is delayed, clinically relevant interactions with most oral medicines are not expected

PDA risk in short-term insulin use (less than 3 years) is significantly increased, while people who started insulin more than 5 years showed a relatively lower risk (0.50.7 folds) than new starters (Li et al., 2009

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For many individuals, these effects attenuate over time as physiological adaptation occurs, though some patients continue to experience persistent symptoms throughout treatment

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