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At year 2, high-density lipoprotein cholesterol significantly increased with liraglutide 2.4/3.0 mg versus orlistat (treatment difference 0.07 mmol l 1 , P =0.03), and both low-density lipoprotein cholesterol and triglycerides decreased from randomization with liraglutide 2.4/3.0 mg (treatment difference 0.12 mmol l 1 for triglycerides, P =0.053 versus orlistat)

C12 stimulate GLP-1 secretion, whereas C10 do not.56 Regarding the relationship between GLP-1 and macronutrients in controlling food intake, a study showed that maintenance on high-fat diet in rats impairs GLP-1s ability to reduce food intake, contributing to overconsumption of high-fat foods.80 Gut hormones and obesity The epidemic obesity is fastly becoming one of the leading causes of mortality and morbidity worldwide