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Factors such as solubility, bioavailability, biological half-life, route of administration, product shelf life, as well as other pharmacological considerations are contemplated herein and the preparation of such pharmaceutical formulations or compositions is presented herein

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1974 New York Verlag Chemic:67384 11

In a similar study among Chinese neonates, this test showed a sensitivity of almost 100% in deficient cases involving both males and females with residual enzyme activity below 60% (74)