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Most studies suggest that beta-amyloid buildup is favored least by APOE2 , a bit more by APOE3 , and much more by APOE4 (Belloy et al., 2019)

Igano et al., Bull

10.1016/s0306-4522(00)00182-2 97 OMalleyA.OConnellC.ReganC

RVG29-modified docetaxel-loaded nanoparticles for brain-targeted glioma therapy

A subsequent study supported this finding by demonstrating that the energy expenditure of mice treated with the conjugate resembles that of the heavier control animals undergoing monotherapy treatment with GLP-1 and MK-801 (Extended Data Fig