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Our results demonstrate that fasting is a critical component of the benefits of CR on AD, suggesting that fasting alone or fasting-mimicking diets might help to prevent or delay AD in humans without requiring reductions in energy intake

This molecular configuration enables it to simultaneously engage and activate both incretin signaling pathways, thereby eliciting complementary and synergistic metabolic effects (22, 23)

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Because aging is ongoing and multifactorial, periodic treatment helps maintain benefits across all three pathways over time

Also, additional LDHB silencing in KRAS -mutated A549 cells further reduced cell viability after combined treatment with 4CBA and RSL3 (Supplementary Fig