Middleton RJ, Foley RN, Hegarty J, Cheung CM, McElduff P, Gibson JM, et al
190 Initially, GLP-1 secretion by L-cells was believed to occur in a glucose-dependent manner
Restaurant impact: Spending at fast-food chains, coffee shops and other limited-service eateries falls by 8.0%, reflecting fewer eating occasions rather than shifts in channel preference
Patients should report any new or worsening mood changes, unusual anxiety, or agitation to their provider, as these may reflect underlying psychiatric condition changes or medication response rather than drug interaction
Some researchers have proposed that GIP contributes primarily through potentiation of insulin secretion and direct effects on adipocyte biology, including enhanced lipid storage capacity in subcutaneous fat depots
GLP-1s are changing obesity care but nutrition may be the silent side effect. As Jorge Urbina and colleagues highlight in a 2026 Clinical Obesity narrative review, GLP-1 receptor agonists (e.g., semaglutide, liraglutide, tirzepatide) can predispose some patients to micronutrient and nutritional deficienciesvia appetite suppression, delayed gastric emptying, and altered intake/absorption
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