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Additionally, engineered SpCas9 variants, such as the nuclease-deficient dCas9 fused to different effector domains, enable diverse applications

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Five firms cover nearly three-fourths of Part D enrollees in 2026 Part D enrollment is concentrated in a handful of top plan sponsors, with 5 firms covering 74% of all Part D enrollees in 2026, or 41.9 million out of 56.3 million enrollees (Table 1)