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It has a shelf life of 24 months under these conditions

This elevation in NAD+ activates sirtuin-1 (SIRT1), often referred to as the longevity gene, which plays a vital role in DNA repair, inflammation reduction, and metabolic regulation

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Nicotinamide (niacinamide) does not cause flushing and has fewer side effects, with nausea and liver toxicity reported only at very high intakes ~3 g/day)

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Because NNMT consumes both nicotinamide and SAM, inhibiting the enzyme may alter intracellular 1-MNA, NAD + , SAM, and SAH levels under some experimental conditions