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The primary metabolic pathways occurring in hepatic tissue are sulfation, which predominates in children younger than 12 years old, and glucuronidation, which prevails in adolescents and adults

Similarly, our analysis confirmed the mediation effects of obesity between GLP-1RAs and ED

doi: 10.3389/fragi.2025.1691007 Received 22 August 2025 Revised 30 October 2025 Accepted 06 November 2025 Published 27 November 2025 Volume 6 - 2025 Edited by Kieran Reid, Harvard Medical School, United States Reviewed by Shannon Hernon, Harvard Medical School, United States Nicole Bajdek, Harvard Medical School, United States Updates Copyright 2025 Dinkla, Beavers, Robbins, Akpalu, Wherry, Miller, Beavers, Espinoza, Trejo, Stepanenko and Cortes

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The FDA-approved answer is yes3

Some risk factors are more important than others