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The Neh6 domain is fundamental for Nrf2 alternative degradation since it is rich in serine residues that are subjected to phosphorylation by glycogen synthase kinase-3 (GSK-3)

Glycemic control: In type 2 diabetes patients, HbA1c dropped by 1.32.0% (from ~8.0% to ~6.0%) with 412 mg doses [1]

A monthly supply at moderate doses for both compounds typically runs between $100 and $200 CAD, which is significantly less than prescription GLP-1 medications like Ozempic or Wegovy

Intrinsic clearance and half-life were calculated [1]

doi: 10.3390/nu8030135

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