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Activation of central GLP-1R influences satiety, nausea, and memory formation, as GLP-1 also acts as a brain stem neurotransmitter [16, 17]

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The ability to form sensory associations can be restored with the use of an early GLP-1 receptor agonist drug, liraglutide, a small study found last year

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That being said, its still worth it to be proactive about preventing constipation