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Proteomics analyses of specific protein oxidation and protein expression in aged rat brain and its modulation by L-acetylcarnitine: insights into the mechanisms of action of this proposed therapeutic agent for CNS disorders associated with oxidative stress

Nucleic Acids Res 51 , 59485980 (2023)

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This part will discuss recent data from literature regarding desensitization of the different OR: the impact of the agonist used through the notion of biased agonism, the role of phosphorylation and consequently the kinases involved, the implication of arrestins and OR internalization and their fate after endocytosis