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The logic behind three times weekly dosing relates to semaglutide half-life

Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial

From a practical standpoint, the most defensible position remains planned exposure avoidance: explicit fertility planning, reliable contraception during treatment, label-informed discontinuation before conception attempts, immediate cessation once pregnancy is recognized, and active metabolic maintenance during the washout period to reduce rebound-related gestational risk (132137)

Such work could one-day enable development of secretagogues that promote release of endogenous GLPs from human L-cells

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