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Historical Background and Scientific Context Scientific interest in peptide signalling compounds expanded significantly during the late twentieth century as advances in peptide chemistry enabled researchers to investigate increasingly complex molecular communication systems

General pharmacology of KP-102 (GHRP-2), a potent growth hormone-releasing peptide

Int J Mol Sci 2022;23:14631.ArticlePubMedPMC 86

It is the only medication of its kind currently used to support weight management

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The second stage is Trem2-dependent and is marked by increased expression of genes involves in lipid metabolism and phagocytic pathway genes (e.g., Lpl, Cst , and Cd9 ), causing excessive inflammatory responses and neurodegeneration (Keren-Shaul et al., 2017