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Brain insulin sensitivity is linked to adiposity and body fat distribution
It is licensed in the United States (under the brand name Egrifta) for HIV-associated lipodystrophy but has not been approved by the MHRA for any indication
Metformin must not be used in patients with eGFR below 30ml/min/1.73m2 due to the risk of secondary lactic acidosis and must be used cautiously in patients with eGFR between 30 and 44ml/min/1.73m2, reducing the drug to a maximum of 1000mg/day
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Caroni P, Grandes P (1990 Apr) Nerve sprouting in innervated adult skeletal muscle induced by exposure to elevated levels of insulin-like growth factors