Endoplasmic reticulum is responsible for protein folding and is highly sensitive to changes in the cellular redox state
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Together, these primary data delineate a pathogenic axis spanning focal iron accumulation, peripheralcentral iron imbalance, and ferroptosis susceptibility in early AD. Further evidence shows that ferritin levels in cerebrospinal fluid (CSF) can predict the rate of cognitive decline and are significantly associated with both A-positivity on PET imaging and elevated t-Tau concentrations
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