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Rejuvenation Res 24(5):390396

The S-acetyl molecule bound to glutathione protects glutathione from breaking down in the gastrointestinal tract, so it reaches the bloodstream intact

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In addition to detoxification, glutathione is involved in DNA synthesis and repair, protein synthesis, and immune system support

doi: 10.1159/000320558 45 SreevidyaV

Weaken one side and the other has to work against a rising tide: low glutathione means more oxidative damage for NAD+-dependent repair to clear, and declining NAD+ means less capacity to power that repair in the first place