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Safety evaluation of -lipoic acid supplementation: a systematic review and meta-analysis of randomized placebo-controlled clinical studies

Under the therapeutic concentrations, approximately 60%90% of APAP is metabolized in the liver by glucuronidation and sulfation, with a small part (approximately 5%15%) being metabolized by the cytochrome P450 pathway (CYP450) ( via two pathways to form the toxic intermediate N-acetyl-p-benzoquinone imine (NAPQI) and the non-toxic catechol metabolite 3-hydroxy-APAP (3-OH-APAP) (Figure 1)

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Research spanning over 35 years has established Epithalon's multifaceted biological activities beyond telomere maintenance