Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
B12 deficiency may cause nerve damage, such as numbness and tingling in the hands and feet
Sleep and stress management Fatigue often stems from insufficient sleep rather than nutrient deficiency
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Retesting too soon may still yield an inaccurate result, as the circulating red cell pool will not yet fully reflect normal cell turnover