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Author contributions The following authors: KT, RC, AY, JO, TN, KS, CV, MS, and ET were involved in both subject recruitment and conducting the assays

Acute injuries may respond in 4 weeks, while chronic conditions often benefit from 6-8 week cycles

The micro-infusion device should be sanitized and prepared, ensuring clean and safe usage

5.2.1 Key antioxidant pathways in ferroptosis regulation In critical oxidative stress response pathways, Nrf2/HO-1 signaling is paramount, with Nrf2 serving as a key endogenous antioxidant factor

Methionine plays a central role in the antioxidant defence system by serving as a precursor for glutathione, one of the most critical intracellular antioxidants [92]

Representative compounds include deferoxamine (DFO), deferiprone (DFP), and the novel metal-modulating molecule PBT2 (He et al., 2024