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& Brandt-Kjelsen, A

Research into the role of NGAL in kidney injury could lead to novel approaches to treating chronic kidney disease (8, 171181)

The peptide contains no cysteine but does have susceptible backbone amide bonds and side-chain groups that can be oxidized under ambient conditions

Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

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Quercetin and other flavonoids are known to behave as mild prooxidants resulting in the upregulation of protective genes, such antioxidant enzymes, glutathione, and cytoprotective enzyme Heme Oxygenase HO-1 mediated by activation of the Nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor upregulating antioxidant response, expression of antioxidant enzymes, and cytoprotective proteins (Ma and He 2012)