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Every trial arm except one used this as the entry point, and for good reason

Peptide therapies can also benefit people looking for long-term weight management solutions or individuals with metabolic conditions like insulin resistance

Additional lipid-lowering agents, such as ezetimibe or icosapent ethyl, may be considered in certain cases

NICE guidance supports the use of GLP-1 receptor agonists for type 2 diabetes (NG28) when certain criteria are met, typically after other treatments have been tried

GLP-1 agonists have clear cardiovascular benefits

Tesamorelin plus tirzepatide Tirzepatide dual-agonist approach (GLP-1 plus GIP) sits between semaglutide and retatrutide in both efficacy and novelty