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It was first characterized by Sikiric and colleagues at the University of Zagreb, who were investigating why the stomach lining tolerates such a harsh environment

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Among the diseases it can potentially treat are Parkinson's disease, Alzheimer's disease, and Huntington's disease

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In this study with OVA-inhaled mice, the increased ROS generation, the increased levels of Th2 cytokines and VEGF, the increased vascular permeability, the increased mucus production, and the increased airway resistance in the lungs were significantly reduced by the administration of AD4