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In fact, this type of injury can be graded on a scale of severity, from 1 to 4

In *in vitro* experiments, durian extract can effectively suppress the levels of inflammatory factors such as tumor necrosis factor-alpha (TNF-), interleukin-6 (IL-6), interleukin-1 (IL-1), NO, and the transcription factor nuclear factor-kappa B (NF-B), while increasing the levels of anti-inflammatory factors such as IL-10

It is thought that this peptide functions by encouraging angiogenesis, the development of new blood vessels, which is essential for tissue healing

J Mol Med 95(3):239248 Zhang X, Zhu JX, Ma ZG, Wu HM, Xu SC, Song P, Kong CY, Yuan YP, Deng W, Tang QZ (2019) Rosmarinic acid alleviates cardiomyocyte apoptosis via cardiac fibroblast in doxorubicin-induced cardiotoxicity

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