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Similar content being viewed by others Introduction The liver is a vital organ that governs over hundreds of physiological processes, including nutrient metabolism 1 , detoxification 2 , bile secretion 3 , and protein synthesis 1 , serving as the bodys primary metabolic hub 4,5

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There are three main biotransformation pathways (see Figure 2) involved in methamphetamine metabolic clearance: (1) N-demethylation to produce amphetamine, (2) aromatic hydroxylation producing 4-hydroxymethamphetamine (pholedrine) with both reactions partially regulated by CYP2D6 (Lin et al., 1997), and (3) beta-hydroxylation to produce norephedrine