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These receptors likely collaborate with GLP-1Rs in other brain regions, collectively mediating the anorectic and body weightlowering effects of liraglutide (9, 26, 49)
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However, multiple areas within the CNS (such as area postrema and nucleus tractus solitarii ) appear to transduce pharmacological signals that connect GLP-1R activation with suppressed food consumption and weight reduction [39]
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36 Liraglutide seems to offer a body-weight loss of 46 kg compared to placebo, 37 while the protective effect on cardiovascular outcomes (lower rates of myocardial infarction, stroke and death) is notable, 38 as is the lower rates of diabetes nephropathy development and progression
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