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Elevated markers may indicate heightened visceral sensitivity or intestinal barrier dysfunction, informing slower titration or alternative approaches

A call for caution and for further investigations in these groups of people, including those with pre-existing psychiatric disorders, such as depression, is probably justified. However, Stephen Evans, emeritus professor of pharmacoepidemiology at the London School of Hygiene and Tropical Medicine, said: In my view, this is not a significant or noteworthy paper, and it has major limitations