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(C) mRNA expression of Ptgs2

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Beyond that, the evidence is per-compound plus the CagriSema (cag + sema) Phase 3 data as the closest human analog

Any discussion of interactions at this stage is therefore based on pharmacological reasoning and extrapolation from related, licensed GLP-1 receptor agonists such as semaglutide (Ozempic, Wegovy) and tirzepatide

Quick Answer: Patients with Hashimoto's thyroiditis can generally use tirzepatide for type 2 diabetes or weight management when appropriately indicated, though thyroid function monitoring and potential levothyroxine dose adjustments are necessary