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Abstract Cobalamin is a water-soluble molecule that has an important role in cellular metabolism, especially in DNA synthesis, methylation, and mitochondrial metabolism

Vincristine caused a sharp increase in histone 3 phosphorylation at serine 10 (pS10-H3), likely due to its interference with mitotic spindle assembly, causing mitotic arrest ( Supplementary Figure S7A )

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Together, these peptides act on core hallmarks of aging: inflammation, oxidative stress, mitochondrial decline, and extracellular matrix degradation