Example of a microdosing schedule: Weeks 1-4: 1.0 mg once weekly Weeks 5-8: 1.5 mg once weekly Weeks 9-12: 2.0 mg once weekly Week 13+: Transition to the standard 2.5 mg dose, then follow the standard escalation schedule
According to clinical trial data for semaglutide: nausea (up to 44% of patients) and diarrhoea (~30%) are the top complaints , followed by vomiting (~24%), constipation, and general stomach discomfort
Alcohol offers empty calories, bloating, and, with GLP-1, a reduced dopamine reward: and is therefore often the first thing to be cut. The long term effect of GLP-1 consumption on alcohol is not yet known: but the direction of travel is clear.
patients (with matched cohorts totaling thousands), it found increased risks of pancreatitis, bowel obstruction, and gastroparesis compared to bupropion-naltrexone, a weight loss medication
In people with diabetes, especially those who use insulin, the production of amylin is impaired, which contributes to postprandial blood glucose spikes
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