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12 Because its oxidative functions require GSH to be in its reduced form, GSSG is reduced to regenerate GSH in a reaction catalyzed by GSH reductase that requires reduced nicotinamide adenine dinucleotide phosphate (NADPH) as a hydrogen donor (Figure 2)

Lofton errs on the side of caution and recommends avoiding compounded versions altogether

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Lipid metabolism also shifted, with an increase in acylcarnitine in MIA PaCa II cells across all treatments, including SHP099 monotherapy (Supplementary Fig

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