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Key findings include a 70% increase in skin thickness after 12 days of topical application, wrinkle volume reduction of 55.8% and depth reduction of 32.8% in clinical studies, and accelerated wound healing across multiple models (Pickart et al., 2018)

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But a small 2018 study found that taking higher dosage oral supplements (1,000 to 2,000 mcg) improves B12 levels about as effectively as injections

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