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Brain Activation Studies Neuroanatomical studies using c-Fos immunoreactivity (a marker of neuronal activation) mapped PT-141s central effects: Activation concentrated in hypothalamic nuclei including mPOA, paraventricular nucleus, and arcuate nucleus Limbic system activation in regions processing reward and motivation Dose-dependent activation patterns correlating with behavioral responses Selective activation in regions known to control sexual function across species Clinical Translation Gap: Despite robust preclinical evidence and successful Phase 3 trials in women, PT-141 currently has FDA approval only for premenopausal women with HSDD

When weight stabilizes, they may perceive the medication as less effective and discontinue therapy prematurely

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Semple et al, 2013) with some processes peaking between after 3 yr of age (Huttenlocher & Dabholkar, 1997)

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