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According to the FDA, 7 black-box warnings are placed when: an adverse reaction so significant exists that this potential negative effect must be considered in risks and benefits when prescribing the medication a serious adverse reaction exists that can be prevented, or the risk reduced, by appropriate use of the medication the FDA has approved the medication with restrictions to ensure safe use

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Semaglutide and Tirzepatide both have potential side effects, such as gastrointestinal issues

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Certain health conditions and life circumstances can make these drugs unsuitable or even dangerous