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(2) Variability-driven regulatory failure: Coefficients of variation exceeding 50%60% preclude bioequivalence demonstration for dose-critical molecules whose therapeutic effects depend on achieving specific concentrations at specific times

Schnemann HJ, Higgins JP, Vist GE, et al

New York: Springer (2016)

In serious cases, it may cause adverse consequences such as blurred vision and dry eyes

J Hepatol (2011) 54(4):795809

Moreover, the outcome of an agonist of one receptor (GLP-1R, AMYR or GHSR) show the opposite results as the antagonist of the same receptor (45, 56, 58)