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Endocr Pract 2015;21:81422

PF-06372222 and key residues are shown as sticks

Basic science experiments demonstrated weight-independent immunomodulatory effects of GLP-1 analogs through inhibition of the NF-B pathway (via AMP-activated protein kinase phosphorylation in psoriasis and prevention of IB phosphorylation in rheumatoid arthritis), the researchers wrote

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In the LEADER study, the group treated with liraglutide had a lower risk of nephropathy, with a reduction of 26% ( The FLOW trial enrolled 3533 patients with T2DM and chronic kidney disease at high risk for kidney failure, cardiovascular events, and death

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