glp-1 side effects depression Your guide to GLP-1 and Depression: Mental Health

doi:10.1016/j.biopha.2020.110137

RWD provides the depth and breadth needed to address critical questions, revealing how GLP-1s perform across medical histories, comorbidities, label expansions, and populations not studied in clinical trials (such as pregnant women)

At 68 weeks (roughly 16 months), the STEP 1 trial showed average weight loss of 14.9% with semaglutide versus 2.4% with placebo

GLP-1 agonists reduce insulin levels, and lower insulin triggers the kidneys to release stored sodium and water

15 Who May Benefit Most From GLP-1s for Heart Health By addressing the root drivers of heart disease including inflammation, insulin resistance, and liver stress GLP-1s can be a powerful tool for anyone with significant cardiovascular risk, even if their weight is in the normal BMI range

& Sharma, K