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Injection site reactions, including bruising, are documented adverse effects in semaglutide clinical trials, though bruising is not separately reported in FDA labeling

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Finally, tirzepatide was associated with significantly reduced occurrence of a composite kidney outcome comprising new-onset MA, 40% eGFR decline, end-stage renal disease and death due to kidney failure (HR 0.58, 95% CI 0.430.80) [49]

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