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The approval is based on data from the randomized, open-label Phase III PAPILLON trial that showed the Rybrevant-based regimen cut the risk of disease progression or death by 60% versus chemotherapy alone

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Composition: Sterile water with 0.9% benzyl alcohol Form: Multi-use vials Primary Use: Diluent / solvent for reconstitution of lyophilized compounds Storage: Store at controlled room temperature

Roughly 10% of patients on the highest dose of orforglipron quit this trial early, complaining of gastrointestinal issues including nausea, diarrhea, and indigestion