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Excessive doses of Vit A or retinol can surpass the livers ability to store the vitamin, leading to intoxication

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Morphological and Sub-Structural Analysis of Genetically Altered Dendritic Arborization (da) Neurons from the Drosophila Larva, Akhil Goel, Anna Lulushi, Adarsh Mallepally, Margaret Kirtley, Amanda Hsu, Alisha Compton, Oanh Dao, Leah Kiely, Jacinta das, Giorgio Ascoli, Sumit Nanda 3

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These tumors appeared in a dose-dependent manner, with higher incidence at increased drug exposures and longer treatment durations

Instead, compounded alternatives may be prescribed when clinically appropriate and legally permissible