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One example escalation schedule observed in Phase 2 obesity trials proceeded broadly as follows: Weeks 14: 2 mg once weekly (initiation phase) Weeks 58: 4 mg once weekly Weeks 912: 8 mg once weekly Weeks 13 onwards: Up to 12 mg once weekly (the maximum dose explored in Phase 2 trials) This is an illustrative example only

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Her dermatologist explained the hair loss wasnt because tirzepatide is worseits because the tripled rate of weight loss created more metabolic stress

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STANDARDS FOR EVALUATING THE EFFICACY OF OBESITY TREATMENT DRUGS The mechanisms of action and structural formulations of GLP-1RA-based therapies for obesity are detailed in Figs