Unfortunately, it is known that the astrocytic protection afforded to neurons is limited, possibly due to a decline in GSH trafficking by chronic iNOS induction [52]
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In conclusion, we show that chronic in vivo GSH deficiency, despite inducing CYP2E1 and hepatic oxidative stress, triggers adaptive mechanisms that protect the liver against ethanol-induced toxicity
cyclophosphamide, busulfan), platinum salts and ionising radiation, all of which converge on several interconnected pathogenic pathways in the ovary [67,68,69,70]
, L- 0.5-2 ,