Boxplots comparing protein expression of MTA1 between primitive and committed patients in both BeatAML-proteomics (n of primitive = 74 patients, n of committed = 74 patients) and CPTAC AML cohort (n of primitive = 75 patients, n of committed = 75 patients)
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In this study, we identified three genes, AsGGT1 , AsGGT2 , and AsGGT3 , from garlic ( Allium sativum ) that encode -glutamyl transpeptidases (GGTs) catalyzing the removal of the -glutamyl moiety from a putative biosynthetic intermediate of S -allyl-L-cysteine sulfoxide (alliin)
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The piperidinone also engages in the S 1 pocket, where the fluorine on the upstream side forms a hydrogen bond with Tyr631, while the fluorine on the downstream piperidine makes a hydrophobic contact with Tyr666 and Tyr662
