Novel LC-MS/MS analysis of the GLP-1 analogue semaglutide with its application to pharmacokinetics and brain distribution studies in rats
Access this article Similar content being viewed by others Abbreviations ADA: Anti-drug antibody AU: Arbitrary units B/T: Percentage of bound (B) relative to total (T) radioactivity DP: Drug product DPP-IV: Dipeptidyl peptidase-IV DS: Drug substance dSLR: Digital single-lens reflex EC 7080 : 7080% maximal effective concentration GLP-1: Glucagon-like peptide-1 GMP: Good Manufacturing Practice HLA: Human leukocyte antigen HMWP: High-molecular-weight protein HPLC: High-performance liquid chromatography ICPOES: Inductively Coupled Plasma Optical Emission Spectroscopy LC-MS: Liquid chromatography-mass spectrometry LEAD: Liraglutide Effect and Action on Diabetes LOQ: Limit of quantification MHC: Major histocompatibility complex MS: Mass spectrometry nAb: Neutralizing antibody NTU: Nephelometric turbidity units PEG: Polyethylene glycol RP-HPLC: Reverse phase high-performance liquid chromatography s.c.: Subcutaneous SEC: Size exclusion chromatography SUSTAIN: Semaglutide Unabated Sustainability in Treatment of Type 2 Diabetes ThT: Thioflavin T UPLC: Ultra-performance liquid chromatography USP: United States Pharmacopeia References Lau JL, Dunn MK
Follow-on versions of liraglutide and semaglutide, and possibly other polypeptides, should be clinically evaluated for efficacy and safety
Starting earlier and maintaining consistency produces meaningfully different outcomes than episodic use
Liraglutide and Insulin Have Contrary Effects on Adipogenesis of Human Adipose-Derived Stem Cells via Wnt Pathway
Eur J Endocrinol 191(6):G1G17 [DOI] [PubMed] [Google Scholar] 61.Mansur SA, Mieczkowska A, Bouvard B, Flatt PR, Chappard D, Irwin N, Mabilleau G (2015) Stable incretin mimetics counter rapid deterioration of bone quality in type 1 diabetes mellitus
