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The solution is not to increase the dose prematurely

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Weeks 14 establish the foundation

Retatrutide achieved approximately 24 to 28.7% weight loss at its highest dose over 48 to 72 weeks, compared to Mounjaro achieving approximately 20 to 22.5% at its highest dose over 72 weeks

Most of these studies have a combined predefined endpoint of the classical MACE-3 (major adverse cardiovascular endpoint) consisting of cardiovascular death, non-fatal myocardial infarct and non-fatal stroke