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Studies have found that TMAO can significantly reduce the number of mitochondria, membrane potential, and ATP content of oocytes in polycystic ovary syndrome rat models, thus accelerating the apoptosis of oocytes

Furthermore, the interaction between the unliganded -CT and the FnIII-1 domain, together with the disulfide bonds between the two -CTs, restricts the conformational change of unliganded -CT, which is required for the binding of a second IGF1 molecule (Fig

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doi: 10.3389/fneur.2021.701419 263 PagenDMEVan HerckMvan BilsenCJABrinkhuesSKoningsKden HeijerCDJet al

PMCID: PMC10130967

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