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Both HbA1c and body weight reduced significantly from 6.5 to 6.1% and 4.5 +/- 1.5 kg, respectively.[55] Liraglutide treatment provided an additional strategy for improving glycemic control in T1DM and clearly demonstrated improvements in beta cell health as was seen in the LEAD-meta-analysis (improvements in HOMA-beta scores and proinsulin/insulin ratios)

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In a phase II trial, obese participants who were administered retatrutide lost an average of 24.2 percent of their body weight over a 48-week period, Wired noted, which is more than what other drugs have achieved in nearly twice the amount of time